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Article

Identification and characterization of a complete carnitine biosynthesis pathway in Candida albicans.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2009

Strijbis Karin, van Roermund Carlo W T, Hardy Guy P, van den Burg Janny, Bloem Karien, de Haan Jolanda, van Vlies Naomi, Wanders Ronald J A, Vaz Frédéric M, Distel Ben

Abstract excerpt

Carnitine is an essential metabolite that enables intracellular transport of fatty acids and acetyl units. Here we show that the yeast Candida albicans can synthesize carnitine de novo, and we identify the 4 genes of the pathway. Null mutants of orf19.4316 (trimethyllysine dioxygenase), orf19.6306 (trimethylaminobutyraldehyde dehydrogenase), and orf19.7131 (butyrobetaine dioxygenase) lacked their respective...

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PMID: 19289605
DOI: 10.1096/fj.08-127985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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