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Article

Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains.

Antimicrobial agents and chemotherapy - 1 Jun 2009

Yang Soo-Jin, Xiong Yan Q, Dunman Paul M, Schrenzel Jacques, François Patrice, Peschel Andreas, Bayer Arnold S

Abstract excerpt

We used a well-characterized isogenic set of clinical bloodstream Staphylococcus aureus strains to study (i) regulation of mprF-mediated phosphatidylglycerol lysinylation in the contexts of in vitro daptomycin (DAP) nonsuceptibility and (ii) the role of mprF mutation in endovascular virulence. We observed a correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility....

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Source

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Identifiers

PMID: 19289517
DOI: 10.1128/AAC.01415-08
PMCID: PMC2687189

Genes

DAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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