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Article

Modeling effects of human single nucleotide polymorphisms on protein-protein interactions.

Biophysical journal - 18 Mar 2009

Teng Shaolei, Madej Thomas, Panchenko Anna, Alexov Emil

Abstract excerpt

A large set of three-dimensional structures of 264 protein-protein complexes with known nonsynonymous single nucleotide polymorphisms (nsSNPs) at the interface was built using homology-based methods. The nsSNPs were mapped on the proteins' structures and their effect on the binding energy was investigated with CHARMM force field and continuum electrostatic calculations. Two sets of nsSNPs were studied: disease...

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Identifiers

PMID: 19289044
DOI: 10.1016/j.bpj.2008.12.3904
PMCID: PMC2717281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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