Article
Culture of primary epithelial adenoma cells from familial adenomatous polyposis patients.
Anticancer research - 1 Jan 2000
Fostira Florentia, Apessos Angela, Oikonomou Eutyxia, Kouklis Panos, Baratsis Sotiris, Manifikos Grigoris, Andera Ladislav, Yannoukakos Drakoulis, Pintzas Alexander, Nasioulas George
Abstract excerpt
BACKGROUND: Colorectal tumors arise from unregulated cell proliferation of the intestinal epithelium through a multistep process the first step usually being premalignant adenomas. Familial adenomatous polyposis patients carry a germ line mutation in the APC gene leading to the development of thousands of polyps, which, if left untreated, lead to cancer. The goal of this study was the establishment of conditions...
Topics
- Adenoma
- Adenomatous Polyposis Coli
- Cell Culture Techniques
- Colonic Polyps
- Colorectal Neoplasms
- Epithelial Cells
- Humans
- Phenotype