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Article

The headache of a hyperactive calcium channel.

Neuron - 12 Mar 2009

Xue Mingshan, Rosenmund Christian

Abstract excerpt

Migraine is thought to be triggered by excessive neocortical neuronal excitability that leads to cortical spreading depression. In this issue of Neuron, Tottene et al. study a mouse model of familial hemiplegic migraine type 1, and provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical glutamatergic synaptic transmission as an underlying mechanism for the susceptibility of cortical...

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Identifiers

PMID: 19285460
DOI: 10.1016/j.neuron.2009.02.015
PMCID: PMC2734997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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