Article
Association of ABCB1 gene polymorphisms with plasma lipid and apolipoprotein concentrations in the STANISLAS cohort.
Clinica chimica acta; international journal of clinical chemistry - 1 May 2009
Jeannesson Elise, Siest Gérard, Bastien Bérangère, Albertini Laetitia, Aslanidis Charalampos, Schmitz Gerd, Visvikis-Siest Sophie
Abstract excerpt
BACKGROUND: While involvement of ABCB1 is well known in drug transport, its metabolite transport role is not so well understood. Like other ABC transporters, ABCB1 might be implicated in cholesterol homeostasis and ABCB1 polymorphisms which are responsible for drug resistance might affect lipid homeostasis. Our objective was thus to investigate the implication of ABCB1 polymorphisms and haplotypes in the genetic...
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