Article
RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation.
Leukemia - 1 Aug 2009
Kuo M-C, Liang D-C, Huang C-F, Shih Y-S, Wu J-H, Lin T-L, Shih L-Y
Abstract excerpt
Runt-related transcription factor 1 (RUNX1) is essential for normal hematopoiesis. RUNX1 mutations have rarely been reported in chronic myelomonocytic leukemia (CMML). We examined RUNX1 mutations in 81 patients with CMML at initial diagnosis. Mutational analysis was performed on bone marrow samples by direct sequencing of all reverse transcription PCR products amplified with three primer pairs that cover the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.