Article
Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia.
Haematologica - 1 Dec 2011
Grossmann Vera, Kern Wolfgang, Harbich Stefan, Alpermann Tamara, Jeromin Sabine, Schnittger Susanne, Haferlach Claudia, Haferlach Torsten, Kohlmann Alexander
Abstract excerpt
The runt-related transcription factor 1, RUNX1, is crucial in the development of myeloid and lymphoid cell lineages and has been reported to be mutated in myeloid malignancies in approximately 30% of cases. In this study, the mutational status of RUNX1 was investigated in 128 acute lymphoblastic leukemia patients. We detected a mutation rate of 18.3% (13 of 71) in patients with T-cell acute lymphoblastic...
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