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Article

Functional role of J domain of cysteine string protein in Ca2+-dependent secretion from acinar cells.

American journal of physiology. Gastrointestinal and liver physiology - 1 May 2009

Weng Ning, Baumler Megan D, Thomas Diana D H, Falkowski Michelle A, Swayne Leigh Anne, Braun Janice E A, Groblewski Guy E

Abstract excerpt

The heat shock protein 70 family members Hsc70 and Hsp70 are known to play a protective role against the onset of experimental pancreatitis, yet their molecular function in acini is unclear. Cysteine string protein (CSP-alpha) is a zymogen granule (ZG) membrane protein characterized by an NH(2)-terminal "J domain" and a central palmitoylated string of cysteine residues. The J domain functions as a cochaperone by...

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Identifiers

PMID: 19282376
DOI: 10.1152/ajpgi.90592.2008
PMCID: PMC2696211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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