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Th1 Cell Reactivity and HLA‐DR Binding Prediction for Promiscuous Recognition of MPT63 (Rv1926c), a Major Secreted Protein of <i>Mycobacterium tuberculosis</i>

24 Dec 2008

Abstract excerpt

MPT63 (Rv1926c), a major secreted protein of Mycobacterium tuberculosis, is immunoreactive in antibody assays in humans and animals and provides protection as a combined DNA vaccine in mice. This study was undertaken to determine the reactivity of MPT63 in T helper 1 (Th1) cell assays, i.e. antigen-induced proliferation and interferon-gamma secretion, using peripheral blood mononuclear cells (PBMCs) obtained from...

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PMID: 19281533
DOI: 10.1111/j.1365-3083.2008.02221.x

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