PPE Protein (Rv3873) from DNA Segment RD1 of<i>Mycobacterium tuberculosis</i>: Strong Recognition of Both Specific T-Cell Epitopes and Epitopes Conserved within the PPE Family

Abstract excerpt

Proteins encoded by DNA segment RD1 of Mycobacterium tuberculosis have recently been demonstrated to play important roles in bacterial virulence, vaccine development, and diagnostic reagent design. Previously, we characterized two immunodominant T-cell antigens, the early secreted antigen target (ESAT-6) and the 10-kDa culture filtrate protein (CFP10), which are encoded by the esx-lhp operon in this region. In...

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