In silico Analysis and Experimental Validation of <b><i>Mycobacterium tuberculosis</i></b>-Specific Proteins and Peptides of <b><i>Mycobacterium tuberculosis</i></b> for Immunological Diagnosis and Vaccine Development

Abstract excerpt

Comparative analyses of the Mycobacterium tuberculosis genome with the genomes of other mycobacteria have led to the identification of several genomic regions of difference (RDs) between M. tuberculosis and M. bovis BCG. The identification of immunodominant and HLA-promiscuous antigens and peptides encoded by these RDs could be useful for diagnosis and the development of new vaccines against tuberculosis. The...

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