Article
Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2004
Shams Homayoun, Klucar Peter, Weis Steven E, Lalvani Ajit, Moonan Patrick K, Safi Hassan, Wizel Benjamin, Ewer Katie, Nepom Gerald T, Lewinsohn David M, Andersen Peter, Barnes Peter F
Abstract excerpt
The secreted Mycobacterium tuberculosis 10-kDa culture filtrate protein (CFP)10 is a potent T cell Ag that is recognized by a high percentage of persons infected with M. tuberculosis. We determined the molecular basis for this widespread recognition by identifying and characterizing a 15-mer peptide, CFP10(71-85), that elicited IFN-gamma production and CTL activity by both CD4(+) and CD8(+) T cells from persons...
Topics
- Alleles
- Amino Acid Substitution
- Antigens, Bacterial
- Bacterial Proteins
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cytotoxicity, Immunologic
- Epitopes
- HLA Antigens