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Gene duplication and functional divergence of the zebrafish insulin‐like growth factor 1 receptors

16 May 2006

Abstract excerpt

Insulin-like growth factor (IGF) 1 receptor (IGF1R)-mediated signaling plays key roles in growth, development, and physiology. Recent studies have shown that there are two distinct ig f1r genes in zebrafish, termed ig f1ra and ig f1rb. In this study, we tested the hypothesis that zebrafish ig f1ra and ig f1rb resulted from a gene duplication event at the ig f1r locus and that this has led to their functional...

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PMID: 16705083
DOI: 10.1096/fj.05-3882fje

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