Article
The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals.
Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2018
Younis Shady, Schönke Milena, Massart Julie, Hjortebjerg Rikke, Sundström Elisabeth, Gustafson Ulla, Björnholm Marie, Krook Anna, Frystyk Jan, Zierath Juleen R, Andersson Leif
Abstract excerpt
A single nucleotide substitution in the third intron of insulin-like growth factor 2 (IGF2) is associated with increased muscle mass and reduced subcutaneous fat in domestic pigs. This mutation disrupts the binding of the ZBED6 transcription factor and leads to a threefold up-regulation of IGF2 expression in pig skeletal muscle. Here, we investigated the biological significance of ZBED6-IGF2 interaction in the...
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