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Article

Association of anticholinergic medications and AD biomarkers with incidence of MCI among cognitively normal older adults.

Neurology - 20 Oct 2020

Weigand Alexandra J, Bondi Mark W, Thomas Kelsey R, Campbell Noll L, Galasko Douglas R, Salmon David P, Sewell Daniel, Brewer James B, Feldman Howard H, Delano-Wood Lisa

Abstract excerpt

OBJECTIVE: To determine the cognitive consequences of anticholinergic medications (aCH) in cognitively normal older adults as well as interactive effects of genetic and CSF Alzheimer disease (AD) risk factors. METHODS: A total of 688 cognitively normal participants from the Alzheimer's Disease Neuroimaging Initiative were evaluated (mean age 73.5 years, 49.6% female). Cox regression examined risk of progression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32878992
DOI: 10.1212/WNL.0000000000010643
PMCID: PMC7713781

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