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Article

Apolipoprotein E ε4 Modifies the Effect of Possible Anticholinergic Drugs on Incident Dementia: The Shanghai Aging Study.

Journal of the American Medical Directors Association - 1 Apr 2023

Chi Danyi, Wu Wanqing, Zhao Qianhua, Xiao Zhenxu, Luo Jianfeng, Wang Bin, Ding Ding

Abstract excerpt

OBJECTIVES: To validate the hypothesis that apolipoprotein E (APOE) ε4 modifies the effect of possible anticholinergic drugs (PACDs) on incident dementia among older adults. DESIGN: A population-based prospective study. SETTING AND PARTICIPANTS: Dementia-free older adults in an urban community in Shanghai, China. METHODS: At baseline, PACDs were defined according to the Anticholinergic Cognitive Burden Scale....

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PMID: 36842452
DOI: 10.1016/j.jamda.2023.01.018

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