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Article

E6 and e7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cells.

Journal of the National Cancer Institute - 18 Mar 2009

Rampias Theodore, Sasaki Clarence, Weinberger Paul, Psyrri Amanda

Abstract excerpt

BACKGROUND: The E6 and E7 genes of human papillomavirus type 16 (HPV16) encode oncoproteins that bind and degrade p53 and retinoblastoma (pRb) tumor suppressors, respectively. We examined the effects of repressing E6 and E7 oncogene expression on the transformed phenotype of HPV16-positive oropharyngeal cancer cell lines. METHODS: Human oropharyngeal squamous cell cancer 147T and 090 (harboring integrated HPV16...

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Source

Identifiers

PMID: 19276448
DOI: 10.1093/jnci/djp017

Genes

DEK
FAS
MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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