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Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: Repression ofE6/E7-oncogene expression and induction of apoptosis

15 Nov 1996

Abstract excerpt

The E6 gene of tumor-associated types of human papillomaviruses codes for a functional antagonist of p53. Overexpression of E6 from heterologous promoters can block p53-mediated cellular responses to DNA damage, such as transcriptional stimulation of p53 target genes and cell-cycle arrest in G1. In contrast, genotoxic treatment of HPV-positive cancer cells, which express the E6 gene from chromosomally integrated...

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PMID: 8945623
DOI: 10.1002/(sici)1097-0215(19961115)68:4<506::aid-ijc17>3.0.co;2-2

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