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Article

Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents.

Journal of proteome research - 1 May 2009

Waldram Alison, Holmes Elaine, Wang Yulan, Rantalainen Mattias, Wilson Ian D, Tuohy Kieran M, McCartney Anne L, Gibson Glenn R, Nicholson Jeremy K

Abstract excerpt

Covariation in the structural composition of the gut microbiome and the spectroscopically derived metabolic phenotype (metabotype) of a rodent model for obesity were investigated using a range of multivariate statistical tools. Urine and plasma samples from three strains of 10-week-old male Zucker rats (obese (fa/fa, n=8), lean (fa/-, n=8) and lean (-/-, n=8)) were characterized via high-resolution 1H NMR...

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PMID: 19275195
DOI: 10.1021/pr8009885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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