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Article

Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance.

Cell reports - 5 Jul 2017

Dumas Marc-Emmanuel, Rothwell Alice R, Hoyles Lesley, Aranias Thomas, Chilloux Julien, Calderari Sophie, Noll Elisa M, Péan Noémie, Boulangé Claire L, Blancher Christine, Barton Richard H, Gu Quan, Fearnside Jane F, Deshayes Chloé, Hue Christophe, Scott James, Nicholson Jeremy K, Gauguier Dominique

Abstract excerpt

The influence of the gut microbiome on metabolic and behavioral traits is widely accepted, though the microbiome-derived metabolites involved remain unclear. We carried out untargeted urine 1H-NMR spectroscopy-based metabolic phenotyping in an isogenic C57BL/6J mouse population (n = 50) and show that microbial-host co-metabolites are prodromal (i.e., early) markers predicting future divergence in metabolic...

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Identifiers

PMID: 28683308
DOI: 10.1016/j.celrep.2017.06.039
PMCID: PMC5507771

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