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Article

Age and Microenvironment Outweigh Genetic Influence on the Zucker Rat Microbiome

18 Sept 2014

Abstract excerpt

Animal models are invaluable tools which allow us to investigate the microbiome-host dialogue. However, experimental design introduces biases in the data that we collect, also potentially leading to biased conclusions. With obesity at pandemic levels animal models of this disease have been developed; we investigated the role of experimental design on one such rodent model. We used 454 pyrosequencing to profile...

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PMID: 25232735
DOI: 10.1371/journal.pone.0100916

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