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Article

Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes.

Cell reports - 14 Feb 2017

Kreznar Julia H, Keller Mark P, Traeger Lindsay L, Rabaglia Mary E, Schueler Kathryn L, Stapleton Donald S, Zhao Wen, Vivas Eugenio I, Yandell Brian S, Broman Aimee Teo, Hagenbuch Bruno, Attie Alan D, Rey Federico E

Abstract excerpt

Genetic variation drives phenotypic diversity and influences the predisposition to metabolic disease. Here, we characterize the metabolic phenotypes of eight genetically distinct inbred mouse strains in response to a high-fat/high-sucrose diet. We found significant variation in diabetes-related phenotypes and gut microbiota composition among the different mouse strains in response to the dietary challenge and...

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Identifiers

PMID: 28199845
DOI: 10.1016/j.celrep.2017.01.062
PMCID: PMC5325228

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