Article
Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health.
Gut - 1 Nov 2021
Brial François, Chilloux Julien, Nielsen Trine, Vieira-Silva Sara, Falony Gwen, Andrikopoulos Petros, Olanipekun Michael, Hoyles Lesley, Djouadi Fatima, Neves Ana L, Rodriguez-Martinez Andrea, Mouawad Ghiwa Ishac, Pons Nicolas, Forslund Sofia, Le-Chatelier Emmanuelle, Le Lay Aurélie, Nicholson Jeremy, Hansen Torben, Hyötyläinen Tuulia, Clément Karine, Oresic Matej, Bork Peer, Ehrlich Stanislav Dusko, Raes Jeroen, Pedersen Oluf Borbye, Gauguier Dominique, Dumas Marc-Emmanuel
Abstract excerpt
OBJECTIVE: Gut microbial products are involved in regulation of host metabolism. In human and experimental studies, we explored the potential role of hippurate, a hepatic phase 2 conjugation product of microbial benzoate, as a marker and mediator of metabolic health. DESIGN: In 271 middle-aged non-diabetic Danish individuals, who were stratified on habitual dietary intake, we applied 1H-nuclear magnetic resonance...
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