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Article

In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus.

Antimicrobial agents and chemotherapy - 1 May 2009

Oppegard Lisa M, Hamann Bree L, Streck Kathryn R, Ellis Keith C, Fiedler Hans-Peter, Khodursky Arkady B, Hiasa Hiroshi

Abstract excerpt

Simocyclinone D8 (SD8) exhibits antibiotic activity against gram-positive bacteria but not against gram-negative bacteria. The molecular basis of the cytotoxicity of SD8 is not fully understood, although SD8 has been shown to inhibit the supercoiling activity of Escherichia coli gyrase. To unders...

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Identifiers

PMID: 19273673
DOI: 10.1128/AAC.01440-08
PMCID: PMC2681514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19273673-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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