Article
The immune control of HTLV-1 infection: selection forces and dynamics.
Frontiers in bioscience (Landmark edition) - 1 Jan 2009
Bangham Charles R M, Meekings Kiran, Toulza Frederic, Nejmeddine Mohamed, Majorovits Endre, Asquith Becca, Taylor Graham P
Abstract excerpt
Cytotoxic T lymphocytes (CTLs) play a central role in the protective immune response to human T-lymphotropic virus 1 (HTLV-1). Here we consider two questions. First, what determines the strength of an individual's HTLV-1-specific CTL response? Second, what controls the rate of expression of HTLV-1 in vivo, which is greater in patients with HAM/TSP than in asymptomatic carriers with the same proviral load? Recent...
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