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Article

HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals.

Retrovirology - 30 May 2012

Satou Yorifumi, Utsunomiya Atae, Tanabe Junko, Nakagawa Masanori, Nosaka Kisato, Matsuoka Masao

Abstract excerpt

BACKGROUND: HTLV-1 utilizes CD4 T cells as the main host cell and maintains the proviral load via clonal proliferation of infected CD4+ T cells. Infection of CD4+ T cells by HTLV-1 is therefore thought to play a pivotal role in HTLV-1-related pathogenicity, including leukemia/lymphoma of CD4+ T cells and chronic inflammatory diseases. Recently, it has been reported that a proportion of HTLV-1 infected CD4+ T...

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Identifiers

PMID: 22647666
DOI: 10.1186/1742-4690-9-46
PMCID: PMC3403885

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