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Article

STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response.

Journal of biomedical science - 19 Feb 2009

Chen Lan-Sun, Wei Pei-Chi, Liu Taming, Kao Chung-Hsuan, Pai Li-Mei, Lee Chien-Kuo

Abstract excerpt

Interferons (IFNs) are key regulators for both innate and adaptive immune responses. By screening ENU-mutagenized mice, we identified a pedigree- P117 which displayed impaired response to type I, but not type II, IFNs. Through inheritance test, genetic mapping and sequencing, we found a T to A point mutation in the 5' splice site of STAT2 intron 4-5, leading to cryptic splicing and frame shifting. As a result,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19272190
DOI: 10.1186/1423-0127-16-22
PMCID: PMC2653529

Genes

STAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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