Article
ADAMTS13 deficiency with elevated levels of ultra-large and active von Willebrand factor in P. falciparum and P. vivax malaria.
The American journal of tropical medicine and hygiene - 1 Mar 2009
de Mast Quirijn, Groot Evelyn, Asih Puji B, Syafruddin Din, Oosting Marije, Sebastian Silvie, Ferwerda Bart, Netea Mihai G, de Groot Philip G, van der Ven Andre J A M, Fijnheer Rob
Abstract excerpt
A deficiency in ADAMTS13 (a von Willebrand factor [VWF] cleaving protease) is associated with accumulation of prothrombogenic unusually large VWF multimers (UL-VWF) in plasma. We studied VWF release and proteolysis in patients with symptomatic Plasmodium falciparum or P. vivax malaria on the Indonesian island Sumba. Malaria patients had significantly lower platelet counts and higher VWF concentrations and VWF...
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