Article
Association of ADAMTS13 polymorphism with cerebral malaria.
Malaria journal - 14 Dec 2011
Kraisin Sirima, Naka Izumi, Patarapotikul Jintana, Nantakomol Duangdao, Nuchnoi Pornlada, Hananantachai Hathairad, Tsuchiya Naoyuki, Ohashi Jun
Abstract excerpt
BACKGROUND: Cerebral malaria is one of the most severe manifestations of Plasmodium falciparum malaria. The sequestration of parasitized red blood cells (PRBCs) to brain microvascular endothelium has been shown to contribute to the pathophysiology of cerebral malaria. Recent studies reported increased levels of von Willebrand factor (VWF) and reduced activity of VWF-cleaving protease, ADAMTS13 (a disintegrin and...
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