Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The balance between von-Willebrand factor and its cleaving protease ADAMTS13: biomarker in systemic inflammation and development of organ failure?

Current molecular medicine - 1 Mar 2010

Claus R A, Bockmeyer C L, Sossdorf M, Lösche W

Abstract excerpt

PURPOSE: This review investigates and highlights the activity of Willebrand factor (VWF) and its cleaving protease as biomarkers of the development of multiple organ dysfunction in infectious and noninfectious systemic inflammatory response syndrome. STATE OF THE ART: Ultra-large VWF (ULVWF) multimers activate platelets resulting in a prothrombotic situation. Systemic inflammation is associated with increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to ADAMTS13 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers

Share to Blood Platelets

Share to Inflammation

Share to Multiple Organ Failure

Share to Platelet Activation

Share to Sepsis

Source

Identifiers

PMID: 20196724
DOI: 10.2174/156652410790963367

Genes

ADAMTS13
VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The balance between von-Willebrand factor and its cleaving protease ADAMTS13: biomarker in systemic inflammation and development of organ failure?PMID 20196724Read ↗

Severity-stratified and longitudinal analysis of VWF/ADAMTS13 imbalance, altered fibrin crosslinking and inhibition of fibrinolysis as contributors to COVID-19 coagulopathySemantic proximity Read ↗

An update on the pathogenesis and diagnosis of thrombotic thrombocytopenic purpura.Semantic proximity Read ↗

ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura.Semantic proximity Read ↗

Acute Respiratory Distress Syndrome as an Organ Phenotype of Vascular Microthrombotic Disease: Based on Hemostatic Theory and Endothelial Molecular Pathogenesis.Semantic proximity Read ↗

Molecular Pathogenesis of Endotheliopathy and Endotheliopathic Syndromes, Leading to Inflammation and Microthrombosis, and Various Hemostatic Clinical Phenotypes Based on "Two-Activation Theory of the Endothelium" and "Two-Path Unifying Theory" of Hemostasis.Semantic proximity Read ↗

Molecular basis of ADAMTS13 dysfunction in thrombotic thrombocytopenic purpura.Semantic proximity Read ↗

COVID-19 Sepsis: Pathogenesis and Endothelial Molecular Mechanisms Based on "Two-Path Unifying Theory" of Hemostasis and Endotheliopathy-Associated Vascular Microthrombotic Disease, and Proposed Therapeutic Approach with Antimicrothrombotic Therapy.Semantic proximity Read ↗

von Willebrand factor: two sides of a coin.Semantic proximity Read ↗

Interrelationship between COVID-19 and coagulopathy: pathophysiological and clinical evidenceSemantic proximity Read ↗

Covid-19-associated coagulopathy (CoAC): thrombin burst and insufficient fibrinolysis leading to bad outcome.Semantic proximity Read ↗

The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventionsSemantic proximity Read ↗

ADAMTS13 deficiency with elevated levels of ultra-large and active von Willebrand factor in P. falciparum and P. vivax malaria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.