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Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses

6 Mar 2009

Abstract excerpt

nsp1 protein of severe acute respiratory syndrome coronavirus (SARS-CoV), a group 2b CoV, suppresses host gene expression by promoting host mRNA degradation and translation inhibition. The present study analyzed the activities of nsp1 proteins from the group 2 bat CoV strains Rm1, 133, and HKU9-1, belonging to groups 2b, 2c, and 2d, respectively. The host mRNA degradation and translational suppression activities...

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PMID: 19264783
DOI: 10.1128/jvi.02485-08

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