Article
Genetic variability of the prion protein gene (PRNP) in wild ruminants from Italy and Scotland.
Journal of veterinary science - 1 Jun 2009
Peletto Simone, Perucchini Matteo, Acín Cristina, Dalgleish Mark P, Reid Hugh W, Rasero Roberto, Sacchi Paola, Stewart Paula, Caramelli Maria, Ferroglio Ezio, Bozzetta Elena, Meloni Daniela, Orusa Riccardo, Robetto Serena, Gennero Silvia, Goldmann Wilfred, Acutis Pier Luigi
Abstract excerpt
The genetics of the prion protein gene (PRNP) play a crucial role in determining the relative susceptibility to transmissible spongiform encephalopathies (TSEs) in several mammalian species. To determine the PRNP gene variability in European red deer (Cervus elaphus), roe deer (Capreolus capreolus) and chamois (Rupicapra rupicapra), the PRNP open reading frame from 715 samples was analysed to reveal a total of...
Topics
- Animals
- Base Sequence
- DNA
- Deer
- Genetic Predisposition to Disease
- Genetic Variation
- Haplotypes
- Italy
- Molecular Sequence Data
- Phylogeny