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Article

CA125/MUC16 is dispensable for mouse development and reproduction.

PloS one - 1 Jan 2009

Cheon Dong-Joo, Wang Ying, Deng Jian Min, Lu Zhen, Xiao Lianchun, Chen Chun-Ming, Bast Robert C, Behringer Richard R

Abstract excerpt

Cancer antigen 125 (CA125) is a blood biomarker that is routinely used to monitor the progression of human epithelial ovarian cancer (EOC) and is encoded by MUC16, a member of the mucin gene family. The biological function of CA125/MUC16 and its potential role in EOC are poorly understood. Here we report the targeted disruption of the of the Muc16 gene in the mouse. To generate Muc16 knockout mice, 6.0 kb was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19262696
DOI: 10.1371/journal.pone.0004675
PMCID: PMC2650410

Genes

MUC16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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