Article
Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates.
Leukemia - 1 May 2009
Tefferi A, Levine R L, Lim K-H, Abdel-Wahab O, Lasho T L, Patel J, Finke C M, Mullally A, Li C-Y, Pardanani A, Gilliland D G
Abstract excerpt
TET2 (TET oncogene family member 2) is a candidate tumor suppressor gene located at chromosome 4q24, and was recently reported to be mutated in approximately 14% of patients with JAK2V617F-positive myeloproliferative neoplasms. We used high-throughput DNA sequence analysis to screen for TET2 mutations in bone marrow-derived DNA from 48 patients with systemic mastocytosis (SM), including 42 who met the 2008 WHO...
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