Article
Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans.
Nature - 23 Apr 2009
Persson Annelie, Gross Einav, Laurent Patrick, Busch Karl Emanuel, Bretes Hugo, de Bono Mario
Abstract excerpt
Behaviours evolve by iterations of natural selection, but we have few insights into the molecular and neural mechanisms involved. Here we show that some Caenorhabditis elegans wild strains switch between two foraging behaviours in response to subtle changes in ambient oxygen. This finely tuned switch is conferred by a naturally variable hexacoordinated globin, GLB-5. GLB-5 acts with the atypical soluble guanylate...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Genetic Variation
- Globins
- Guanylate Cyclase
- Multifactorial Inheritance
- Neurons
- Oxygen
- Receptors, Neuropeptide Y
