Article
Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases.
Neuron - 26 Mar 2009
Zimmer Manuel, Gray Jesse M, Pokala Navin, Chang Andy J, Karow David S, Marletta Michael A, Hudson Martin L, Morton David B, Chronis Nikos, Bargmann Cornelia I
Abstract excerpt
Homeostatic sensory systems detect small deviations in temperature, water balance, pH, and energy needs to regulate adaptive behavior and physiology. In C. elegans, a homeostatic preference for intermediate oxygen (O2) levels requires cGMP signaling through soluble guanylate cyclases (sGCs), proteins that bind gases through an associated heme group. Here we use behavioral analysis, functional imaging, and...
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