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Article

Counterbalance between BAG and URX neurons via guanylate cyclases controls lifespan homeostasis in C. elegans.

The EMBO journal - 29 May 2013

Liu Tiewen, Cai Dongsheng

Abstract excerpt

Lifespan of C. elegans is affected by the nervous system; however, the underlying neural integration still remains unclear. In this work, we targeted an antagonistic neural system consisting of low-oxygen sensing BAG neurons and high-oxygen sensing URX neurons. While ablation of BAG neurons increases lifespan of C. elegans, ablation of URX neurons decreases lifespan. Genetic analysis revealed that BAG and URX...

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Share to Caenorhabditis elegans Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23584532
DOI: 10.1038/emboj.2013.75
PMCID: PMC3671255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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