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Article

Correlation between voriconazole trough plasma concentration and hepatotoxicity in patients with different CYP2C19 genotypes.

International journal of antimicrobial agents - 1 Jul 2009

Matsumoto Kazuaki, Ikawa Kazuro, Abematsu Kazuko, Fukunaga Naoko, Nishida Kentaro, Fukamizu Tomohide, Shimodozono Yoshihiro, Morikawa Norifumi, Takeda Yasuo, Yamada Katsushi

Abstract excerpt

Voriconazole metabolism is mostly mediated via the cytochrome P450 (CYP) 2C19 isozyme. The non-wild (mutant) type of CYP2C19 is generally found in 60-70% of Asian populations. Because the voriconazole trough plasma concentration has been reported to correlate with hepatotoxicity, this study investigated the effect of CYP2C19 polymorphism on the relationship between voriconazole trough concentrations and liver...

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Share to Aryl Hydrocarbon Hydroxylases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19261446
DOI: 10.1016/j.ijantimicag.2009.01.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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