Article
Reduced antigenicity of naturally occurring hepatitis B surface antigen variants with substitutions at the amino acid residue 126.
Intervirology - 1 Jan 2008
Qiu Song, Zhang Jiming, Tian Yongjun, Yang Yinke, Huang Hanju, Yang Dongliang, Lu Mengji, Xu Yang
Abstract excerpt
BACKGROUND: Substitutions at amino acid residue 126 of hepatitis B surface antigen (HBsAg) occur frequently in hepatitis B virus (HBV) isolates from patients with chronic HBV infection. These substitutions occur naturally, but their significance for viral persistence is unclear and requires further investigation. METHODS: We amplified coding regions of HBsAg by PCR using sera from 1 patient chronically infected...
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