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Article

A unique amino acid substitution, T126I, in human genotype C of hepatitis B virus S gene and its possible influence on antigenic structural change.

Gene - 15 Nov 2006

Ren Fengrong, Tsubota Asahito, Hirokawa Takatsugu, Kumada Hiromitsu, Yang Ziheng, Tanaka Hiroshi

Abstract excerpt

Amino acid substitutions in the S gene of hepatitis B virus (HBV), especially in the 'a' determinant region, have been suggested to affect the antigenicity of the virus and the clinical outcome of the infected patient. However, no convincing evidence has been presented for this hypothesis, partly because the 3D structure of the S protein has not been determined. Comparative analysis of viral genes offers an...

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Identifiers

PMID: 16963200
DOI: 10.1016/j.gene.2006.07.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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