Article
Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations.
Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2009
Dror Ron O, Arlow Daniel H, Borhani David W, Jensen Morten Ø, Piana Stefano, Shaw David E
Abstract excerpt
Fully understanding the mechanisms of signaling proteins such as G protein-coupled receptors (GPCRs) will require the characterization of their conformational states and the pathways connecting those states. The recent crystal structures of the beta(2)- and beta(1)-adrenergic receptors in a nominally inactive state constituted a major advance toward this goal, but also raised new questions. Although earlier...
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