Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotype patterns in cancer-related genes with long-range linkage disequilibrium: no evidence of association with breast cancer or positive selection.

European journal of human genetics : EJHG - 1 Feb 2008

Ribas Gloria, Milne Roger L, Gonzalez-Neira Anna, Benítez Javier

Abstract excerpt

The average length of linkage disequilibrium (LD) blocks in European populations is about 22 kb. In this study, we have selected 20 genes with LD blocks larger than 60 kb (with a median length of 88 kb) from a total of 121 cancer-related genes. We observed limited haplotype diversity, with an average of three haplotypes per gene accounting for more than 90% of the diversity, two of these being a Yin-Yang pair in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Genes, Neoplasm

Share to Haplotypes

Share to Linkage Disequilibrium

Share to Pan troglodytes

Share to Selection, Genetic

Source

Identifiers

PMID: 18000525
DOI: 10.1038/sj.ejhg.5201953

Genes

XRCC4
ALDH2
APC
ATM
BRCA1
BRCA2
ERCC6
MLH1
MSH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotype patterns in cancer-related genes with long-range linkage disequilibrium: no evidence of association with breast cancer or positive selection.PMID 18000525Read ↗

Haplotype and linkage disequilibrium architecture for human cancer-associated genes.Semantic proximity Read ↗

Haplotype analysis of eight genes of the monoubiquitinated FANCD2-DNA damage-repair pathway in breast cancer patients.Semantic proximity Read ↗

Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control study.Semantic proximity Read ↗

A genome wide meta-analysis study for identification of common variation associated with breast cancer prognosis.Semantic proximity Read ↗

Common and novel haplotype structures between different types of cancer.Semantic proximity Read ↗

Haplotypes at ATM identify coding-sequence variation and indicate a region of extensive linkage disequilibrium.Semantic proximity Read ↗

A whole genome long-range haplotype (WGLRH) test for detecting imprints of positive selection in human populations.Semantic proximity Read ↗

Haplotypes associated to gene expression in breast cancer: can they lead us to the susceptibility markers?Semantic proximity Read ↗

Rare BRCA1 haplotypes including 3'UTR SNPs associated with breast cancer risk.Semantic proximity Read ↗

The BRCA1 Ashkenazi founder mutations occur on common haplotypes and are not highly correlated with anonymous single nucleotide polymorphisms likely to be used in genome-wide case-control association studies.Semantic proximity Read ↗

Haplotype frequencies in a sub-region of chromosome 19q13.3, related to risk and prognosis of cancer, differ dramatically between ethnic groups.Semantic proximity Read ↗

Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.