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Article

Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row.

Science (New York, N.Y.) - 27 Feb 2009

Zhang Zunyi, Lan Yu, Chai Yang, Jiang Rulang

Abstract excerpt

Mammals have single-rowed dentitions, whereas many nonmammalian vertebrates have teeth in multiple rows. Neither the molecular mechanism regulating iterative tooth initiation nor that restricting mammalian tooth development in one row is known. We found that mice lacking the transcription factor odd-skipped related-2 (Osr2) develop supernumerary teeth lingual to their molars because of expansion of the...

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Identifiers

PMID: 19251632
DOI: 10.1126/science.1167418
PMCID: PMC2650836

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