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MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling Activity

3 Feb 2022

Abstract excerpt

Tooth agenesis is a common structural birth defect in humans that results from failure of morphogenesis during early tooth development. The homeobox transcription factor Msx1 and the canonical Wnt signaling pathway are essential for “bud to cap” morphogenesis and are causal factors for tooth agenesis. Our recent study suggested that Msx1 regulates Wnt signaling during early tooth development by suppressing the...

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PMID: 35114852
DOI: 10.1177/00220345211070583

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