Article
Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer.
BMC cancer - 26 Feb 2009
Ross Phillip L, Cheng Iona, Liu Xin, Cicek Mine S, Carroll Peter R, Casey Graham, Witte John S
Abstract excerpt
BACKGROUND: Carboxypeptidase 4 (CPA4) is a zinc-dependent metallocarboxypeptidase on chromosome 7q32 in a region linked to prostate cancer aggressiveness. CPA4 is involved in the histone hyperacetylation pathway and may modulate the function of peptides that affect the growth and regulation of prostate epithelial cells. We examined the association between genetic variation in CPA4 and intermediate-to-high risk...
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