Article
Podocalyxin variants and risk of prostate cancer and tumor aggressiveness.
Human molecular genetics - 1 Mar 2006
Casey Graham, Neville Phillippa J, Liu Xin, Plummer Sarah J, Cicek Mine S, Krumroy Lisa M, Curran Anthony P, McGreevy Michelle R, Catalona William J, Klein Eric A, Witte John S
Abstract excerpt
We previously reported linkage of a prostate cancer tumor aggressiveness locus to chromosome 7q32-q33, a region also associated with a high frequency of allelic imbalance in prostate tumors. The smallest region of allelic imbalance contains the podocalyxin-like (PODXL) gene, which we evaluate here as a candidate prostate cancer aggressiveness gene mapping to 7q32-q33. DNA from probands of linked families was...
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