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Article

Functional complementation of Glra1(spd-ot), a glycine receptor subunit mutant, by independently expressed C-terminal domains.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Feb 2009

Villmann Carmen, Oertel Jana, Ma-Högemeier Zhan-Lu, Hollmann Michael, Sprengel Rolf, Becker Kristina, Breitinger Hans-Georg, Becker Cord-Michael

Abstract excerpt

The oscillator mouse (Glra1(spd-ot)) carries a 9 bp microdeletion plus a 2 bp microinsertion in the glycine receptor alpha1 subunit gene, resulting in the absence of functional alpha1 polypeptides from the CNS and lethality 3 weeks after birth. Depending on differential use of two splice acceptor sites in exon 9 of the Glra1 gene, the mutant allele encodes either a truncated alpha1 subunit (spd(ot)-trc) or a...

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Identifiers

PMID: 19244519
DOI: 10.1523/JNEUROSCI.4400-08.2009
PMCID: PMC6666244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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