Article
The frameshift mutation oscillator (Glra1(spd-ot)) produces a complete loss of glycine receptor alpha1-polypeptide in mouse central nervous system.
Neuroscience - 1 May 1997
Kling C, Koch M, Saul B, Becker C M
Abstract excerpt
Mice homozygous for the recessive mutation oscillator (Glra1(spd-ot)) suffer from a complex motor disorder leading to death within three weeks after birth. Symptoms of this disorder mimic poisoning by strychnine, the antagonist of the inhibitory glycine receptor. The syndrome has previously been...
Topics
- Acoustic Stimulation
- Animals
- Animals, Newborn
- Blotting, Western
- Central Nervous System
- Female
- Frameshift Mutation
- Male
- Membranes
- Mice
- Mice, Neurologic Mutants
- Phenotype
- Polymerase Chain Reaction
- RNA, Messenger
- Receptors, Glycine
- Reflex, Startle
- Strychnine