Article
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.
PloS one - 1 Jan 2009
Liu Wencheng, Vives-Bauza Cristofol, Acín-Peréz- Rebeca, Yamamoto Ai, Tan Yingcai, Li Yanping, Magrané Jordi, Stavarache Mihaela A, Shaffer Sebastian, Chang Simon, Kaplitt Michael G, Huang Xin-Yun, Beal M Flint, Manfredi Giovanni, Li Chenjian
Abstract excerpt
Mutations in PTEN induced kinase 1 (PINK1), a mitochondrial Ser/Thr kinase, cause an autosomal recessive form of Parkinson's disease (PD), PARK6. Here, we report that PINK1 exists as a dimer in mitochondrial protein complexes that co-migrate with respiratory chain complexes in sucrose gradients....
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